| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNA ligase 3 (110-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LIG3 |
| Gene ID: |
3980 |
| Uniprot ID: |
DNLI3_HUMAN |
| Immunogen Region: |
110-190 aa |
| Specificity: |
DNA Ligase III Polyclonal Antibody detects endogenous levels of DNA Ligase III protein. |
| Immunogen: |
Synthesized peptide derived from DNA Ligase III at the amino acid range 110-190 |
| Function | Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair. |
| Protein Name | Dna Ligase 3Dna Ligase IiiPolydeoxyribonucleotide Synthase Atp 3 |
| Database Links | Reactome: R-HSA-110381Reactome: R-HSA-5649702Reactome: R-HSA-5685939Reactome: R-HSA-5696397Reactome: R-HSA-6782210 |
| Cellular Localisation | Isoform 1: MitochondrionContains An N-Terminal Mitochondrial Transit PeptideIsoform 2: MitochondrionIsoform 3: NucleusLacks The N-Terminal Mitochondrial Transit PeptideIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Dna Ligase 3 antibodyAnti-Dna Ligase Iii antibodyAnti-Polydeoxyribonucleotide Synthase Atp 3 antibodyAnti-LIG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
