Anti-LIG3 antibody (110-190 aa) (STJ92730)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from DNA Ligase III at the amino acid range 110-190
General Information
| Short Description | Rabbit polyclonal anti-DNA ligase 3 (110-190 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LIG3 |
| Gene ID | 3980 |
| Uniprot ID | DNLI3_HUMAN |
| Immunogen | Synthesized peptide derived from DNA Ligase III at the amino acid range 110-190 |
| Immunogen Region | 110-190 aa |
| Specificity | DNA Ligase III Polyclonal Antibody detects endogenous levels of DNA Ligase III protein. |
Additional Info
| Function | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair. |
| Protein Name | Dna Ligase 3Dna Ligase IiiPolydeoxyribonucleotide Synthase Atp 3 |
| Database Links | Reactome: R-HSA-110381Reactome: R-HSA-5649702Reactome: R-HSA-5685939Reactome: R-HSA-5696397Reactome: R-HSA-6782210Reactome: R-HSA-9913635 P49916-1 |
| Cellular Localisation | Isoform 1: MitochondrionContains An N-Terminal Mitochondrial Transit PeptideIsoform 2: MitochondrionIsoform 3: NucleusLacks The N-Terminal Mitochondrial Transit PeptideIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Dna Ligase 3 antibodyAnti-Dna Ligase Iii antibodyAnti-Polydeoxyribonucleotide Synthase Atp 3 antibodyAnti-LIG3 antibody |
Information sourced from Uniprot.org