Western blot analysis of various lysates using LETM1 Rabbit polyclonal antibody (STJ118131) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-LETM1 antibody (1-140) (STJ118131)

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STJ118131
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LETM1
Gene ID: 3954
Uniprot ID: LETM1_HUMAN
Immunogen Region: 1-140
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1).
Immunogen Sequence: MASILLRSCRGRAPARLPPP PRYTVPRGSPGDPAHLSCAS TLGLRNCLNVPFGCCTPIHP VYTSSRGDHLGCWALRPECL RIVSRAPWTSTSVGFVAVGP QCLPVRGWHSSRPVRDDSVV EKSLKSLKDKNKKLEEGGPV
Post Translational Modifications PINK1-mediated phosphorylation at Thr-192, positively regulates its mitochondrial calcium transport activity.
Function Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization.
Protein Name Mitochondrial Proton/Calcium Exchanger Protein
Electroneutral Mitochondrial K(+/H(+Exchanger
Khe
Leucine Zipper-Ef-Hand-Containing Transmembrane Protein 1
Database Links Reactome: R-HSA-8949215
Reactome: R-HSA-9013408
Reactome: R-HSA-9865881
Cellular Localisation Mitochondrion Inner Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Mitochondrial Proton/Calcium Exchanger Protein antibody
Anti-Electroneutral Mitochondrial K(+/H(+Exchanger antibody
Anti-Khe antibody
Anti-Leucine Zipper-Ef-Hand-Containing Transmembrane Protein 1 antibody
Anti-LETM1 antibody

Information sourced from Uniprot.org

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