Anti-LETM1 antibody (1-140) (STJ118131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LETM1 (1-140) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LETM1 |
| Gene ID | 3954 |
| Uniprot ID | LETM1_HUMAN |
| Immunogen Region | 1-140 |
| Immunogen Sequence | MASILLRSCRGRAPARLPPP PRYTVPRGSPGDPAHLSCAS TLGLRNCLNVPFGCCTPIHP VYTSSRGDHLGCWALRPECL RIVSRAPWTSTSVGFVAVGP QCLPVRGWHSSRPVRDDSVV EKSLKSLKDKNKKLEEGGPV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1). |
Additional Info
| Post Translational Modifications | PINK1-mediated phosphorylation at Thr-192, positively regulates its mitochondrial calcium transport activity. |
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Also functions as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. |
| Protein Name | Mitochondrial Proton/Calcium Exchanger ProteinElectroneutral Mitochondrial K(+/H(+ExchangerKheLeucine Zipper-Ef-Hand-Containing Transmembrane Protein 1 |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-9013408Reactome: R-HSA-9865881 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Proton/Calcium Exchanger Protein antibodyAnti-Electroneutral Mitochondrial K(+/H(+Exchanger antibodyAnti-Khe antibodyAnti-Leucine Zipper-Ef-Hand-Containing Transmembrane Protein 1 antibodyAnti-LETM1 antibody |
Information sourced from Uniprot.org