| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LETM1 (1-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LETM1 |
| Gene ID: |
3954 |
| Uniprot ID: |
LETM1_HUMAN |
| Immunogen Region: |
1-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1). |
| Immunogen Sequence: |
MASILLRSCRGRAPARLPPP PRYTVPRGSPGDPAHLSCAS TLGLRNCLNVPFGCCTPIHP VYTSSRGDHLGCWALRPECL RIVSRAPWTSTSVGFVAVGP QCLPVRGWHSSRPVRDDSVV EKSLKSLKDKNKKLEEGGPV |
| Post Translational Modifications | PINK1-mediated phosphorylation at Thr-192, positively regulates its mitochondrial calcium transport activity. |
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. |
| Protein Name | Mitochondrial Proton/Calcium Exchanger ProteinElectroneutral Mitochondrial K(+/H(+ExchangerKheLeucine Zipper-Ef-Hand-Containing Transmembrane Protein 1 |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-9013408 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Proton/Calcium Exchanger Protein antibodyAnti-Electroneutral Mitochondrial K(+/H(+Exchanger antibodyAnti-Khe antibodyAnti-Leucine Zipper-Ef-Hand-Containing Transmembrane Protein 1 antibodyAnti-LETM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
