| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P3H1 |
| Gene ID: | 64175 |
| Uniprot ID: | P3H1_HUMAN |
| Immunogen Region: | 497-736 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 497-736 of human LEPRE1 (NP_071751.3). |
| Immunogen Sequence: | GDGYRGQTSPHTPNEKFYGV TVFKALKLGQEGKVPLQSAH LYYNVTEKVRRIMESYFRLD TPLYFSYSHLVCRTAIEEVQ AERKDDSHPVHVDNCILNAE TLVCVKEPPAYTFRDYSAIL YLNGDFDGGNFYFTELDAKT VTAEVQPQCGRAVGFSSGTE NPHGVKAVTRGQRCAIALWF TLDPRHSERDRVQADDLVKM LFSPEEMDLSQEQPLDAQQG PPEPAQESLSGSESKPKDE |
| Post Translational Modifications | O-glycosylated.chondroitin sulfate. |
| Function | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. |
| Protein Name | Prolyl 3-Hydroxylase 1Growth Suppressor 1Leucine- And Proline-Enriched Proteoglycan 1Leprecan-1 |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Isoform 1: Endoplasmic ReticulumSecretedExtracellular SpaceExtracellular MatrixSecreted Into The Extracellular Matrix As A Chondroitin Sulfate Proteoglycan (Cspg) |
| Alternative Antibody Names | Anti-Prolyl 3-Hydroxylase 1 antibodyAnti-Growth Suppressor 1 antibodyAnti-Leucine- And Proline-Enriched Proteoglycan 1 antibodyAnti-Leprecan-1 antibodyAnti-P3H1 antibodyAnti-GROS1 antibodyAnti-LEPRE1 antibodyAnti-PSEC0109 antibody |
Information sourced from Uniprot.org
