Anti-LEPRE1 antibody (497-736) (STJ112360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LEPRE1 (497-736) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | P3H1 |
| Gene ID | 64175 |
| Uniprot ID | P3H1_HUMAN |
| Immunogen Region | 497-736 |
| Immunogen Sequence | GDGYRGQTSPHTPNEKFYGV TVFKALKLGQEGKVPLQSAH LYYNVTEKVRRIMESYFRLD TPLYFSYSHLVCRTAIEEVQ AERKDDSHPVHVDNCILNAE TLVCVKEPPAYTFRDYSAIL YLNGDFDGGNFYFTELDAKT VTAEVQPQCGRAVGFSSGTE NPHGVKAVTRGQRCAIALWF TLDPRHSERDRVQADDLVKM LFSPEEMDLSQEQPLDAQQG PPEPAQESLSGSESKPKDE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 497-736 of human LEPRE1 (NP_071751.3). |
Additional Info
| Post Translational Modifications | O-glycosylated.chondroitin sulfate. |
| Function | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. |
| Protein Name | Prolyl 3-Hydroxylase 1Growth Suppressor 1Leucine- And Proline-Enriched Proteoglycan 1Leprecan-1 |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Isoform 1: Endoplasmic ReticulumSecretedExtracellular SpaceExtracellular MatrixSecreted Into The Extracellular Matrix As A Chondroitin Sulfate Proteoglycan (Cspg) |
| Alternative Antibody Names | Anti-Prolyl 3-Hydroxylase 1 antibodyAnti-Growth Suppressor 1 antibodyAnti-Leucine- And Proline-Enriched Proteoglycan 1 antibodyAnti-Leprecan-1 antibodyAnti-P3H1 antibodyAnti-GROS1 antibodyAnti-LEPRE1 antibodyAnti-PSEC0109 antibody |
Information sourced from Uniprot.org