| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LDLRAP1 (59-308) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LDLRAP1 |
| Gene ID: |
26119 |
| Uniprot ID: |
ARH_HUMAN |
| Immunogen Region: |
59-308 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 59-308 of human LDLRAP1 (NP_056442.2). |
| Immunogen Sequence: |
EQPKGEELSAAAIKRIVATA KASGKKLQKVTLKVSPRGII LTDNLTNQLIENVSIYRISY CTADKMHDKVFAYIAQSQHN QSLECHAFLCTKRKMAQAVT LTVAQAFKVAFEFWQVSKEE KEKRDKASQEGGDVLGARQD CTPSLKSLVATGNLLDLEET AKAPLSTVSANTTNMDEVPR PQALSGSSVVWELDDGLDEA FSRLAQSRTNPQVLDTGLTA QDMHYAQCLSPVDWDKPDS |
| Tissue Specificity | Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. |
| Function | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression. |
| Protein Name | Low Density Lipoprotein Receptor Adapter Protein 1Autosomal Recessive Hypercholesterolemia Protein |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8964026Reactome: R-HSA-8964038Reactome: R-HSA-9758890 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Low Density Lipoprotein Receptor Adapter Protein 1 antibodyAnti-Autosomal Recessive Hypercholesterolemia Protein antibodyAnti-LDLRAP1 antibodyAnti-ARH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
