| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LAMTOR5 (1-173) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LAMTOR5 |
| Gene ID: |
10542 |
| Uniprot ID: |
LTOR5_HUMAN |
| Immunogen Region: |
1-173 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human LAMTOR5 (NP_006393.2). |
| Immunogen Sequence: |
MEPGAGHLDGHRAGSPSLRQ ALCDGSAVMFSSKERGRCTV INFVPLEAPLRSTPRSRQVT EACGGEGRAVPLGSEPEWSV GGMEATLEQHLEDTMKNPSI VGVLCTDSQGLNLGCRGTLS DEHAGVISVLAQQAAKLTSD PTDIPVVCLESDNGNIMIQK HDGITVAVHKMAS |
| Tissue Specificity | Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection. |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. |
| Protein Name | Ragulator Complex Protein Lamtor5Hepatitis B Virus X-Interacting ProteinHbv X-Interacting ProteinHbx-Interacting ProteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | LysosomeCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor5 antibodyAnti-Hepatitis B Virus X-Interacting Protein antibodyAnti-Hbv X-Interacting Protein antibodyAnti-Hbx-Interacting Protein antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 antibodyAnti-LAMTOR5 antibodyAnti-HBXIP antibodyAnti-XIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
