• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-LAMTOR4 antibody (8-58 aa) (STJ196554)

SKU:
STJ196554

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ragulator complex protein LAMTOR4 (8-58 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LAMTOR4
Gene ID: 389541
Uniprot ID: LTOR4_HUMAN
Immunogen Region: 8-58 aa
Specificity: This antibody detects endogenous levels of CG059 at Human
Immunogen: Synthesized peptide derived from the human CG059 at the amino acid range 8-58
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Protein Name Ragulator Complex Protein Lamtor4
Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed
Database Links Reactome: R-HSA-1632852
Reactome: R-HSA-165159
Reactome: R-HSA-166208
Reactome: R-HSA-380972
Reactome: R-HSA-5628897
Reactome: R-HSA-8943724
Reactome: R-HSA-9639288
Cellular Localisation Lysosome
Alternative Antibody Names Anti-Ragulator Complex Protein Lamtor4 antibody
Anti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed antibody
Anti-LAMTOR4 antibody
Anti-C7orf59 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance