| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ragulator complex protein LAMTOR4 (8-58 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LAMTOR4 |
| Gene ID: | 389541 |
| Uniprot ID: | LTOR4_HUMAN |
| Immunogen Region: | 8-58 aa |
| Specificity: | This antibody detects endogenous levels of CG059 at Human |
| Immunogen: | Synthesized peptide derived from the human CG059 at the amino acid range 8-58 |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. |
| Protein Name | Ragulator Complex Protein Lamtor4 Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1632852 Reactome: R-HSA-165159 Reactome: R-HSA-166208 Reactome: R-HSA-380972 Reactome: R-HSA-5628897 Reactome: R-HSA-8943724 Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor4 antibody Anti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed antibody Anti-LAMTOR4 antibody Anti-C7orf59 antibody |
Information sourced from Uniprot.org