Anti-LAMTOR4 antibody (8-58 aa) (STJ196554)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CG059 at the amino acid range 8-58
General Information
| Short Description | Rabbit polyclonal anti-Ragulator complex protein LAMTOR4 (8-58 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMTOR4 |
| Gene ID | 389541 |
| Uniprot ID | LTOR4_HUMAN |
| Immunogen | Synthesized peptide derived from the human CG059 at the amino acid range 8-58 |
| Immunogen Region | 8-58 aa |
| Specificity | This antibody detects endogenous levels of CG059 at Human |
Additional Info
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. |
| Protein Name | Ragulator Complex Protein Lamtor4Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor4 antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed antibodyAnti-LAMTOR4 antibodyAnti-C7orf59 antibody |
Information sourced from Uniprot.org