Anti-L1CAM antibody (1143-1257) (STJ111291)

Name: Anti-L1CAM antibody (1143-1257) (STJ111291)
SKU: STJ111291
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ111291

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Short Description	Rabbit polyclonal L1CAM (1143-1257) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	L1CAM
Gene ID	3897
Uniprot ID	L1CAM_HUMAN
Immunogen Region	1143-1257
Immunogen Sequence	IKRSKGGKYSVKDKEDTQVD SEARPMKDETFGEYRSLESD NEEKAFGSSQPSLNGDIKPL GSDDSLADYGGSVDVQFNED GSFIGQYSGKKEKEAAGGND SSGATSPINPAVALE
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1143-1257 of human CD171/L1CAM (NP_000416.1).

Function	Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Protein Name	Neural Cell Adhesion Molecule L1 N-Cam-L1 Ncam-L1 Cd Antigen Cd171
Database Links	Reactome: R-HSA-210991 Reactome: R-HSA-373760 Reactome: R-HSA-437239 Reactome: R-HSA-445095 Reactome: R-HSA-445144
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Growth Cone Axon Dendrite Colocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal Neurons In Neurons Detected Predominantly In Axons And Cell Body Weak Localization To Dendrites
Alternative Antibody Names	Anti-Neural Cell Adhesion Molecule L1 antibody Anti-N-Cam-L1 antibody Anti-Ncam-L1 antibody Anti-Cd Antigen Cd171 antibody Anti-L1CAM antibody Anti-CAML1 antibody Anti-MIC5 antibody

Information sourced from Uniprot.org