Anti-KLRF1 antibody (STJ192223)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Killer cell lectin-like receptor subfamily F member 1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLRF1 |
| Gene ID | 51348 |
| Uniprot ID | KLRF1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | KLRF1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity. |
| Function | Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily F Member 1Lectin-Like Receptor F1Activating Coreceptor Nkp80C-Type Lectin Domain Family 5 Member C |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily F Member 1 antibodyAnti-Lectin-Like Receptor F1 antibodyAnti-Activating Coreceptor Nkp80 antibodyAnti-C-Type Lectin Domain Family 5 Member C antibodyAnti-KLRF1 antibodyAnti-CLEC5C antibodyAnti-ML antibody |
Information sourced from Uniprot.org