| Post Translational Modifications | Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity. |
| Function | Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily F Member 1Lectin-Like Receptor F1Activating Coreceptor Nkp80C-Type Lectin Domain Family 5 Member C |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily F Member 1 antibodyAnti-Lectin-Like Receptor F1 antibodyAnti-Activating Coreceptor Nkp80 antibodyAnti-C-Type Lectin Domain Family 5 Member C antibodyAnti-KLRF1 antibodyAnti-CLEC5C antibodyAnti-ML antibody |
Information sourced from Uniprot.org
