| Short Description : | Rabbit polyclonal KLF17 (210-389) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLF17 |
| Gene ID: | 128209 |
| Uniprot ID: | KLF17_HUMAN |
| Immunogen Region: | 210-389 |
| Immunogen Sequence: | QMLPPQDAHDLGMPPAESQS LLVLGSQDSLVSQPDSQEGP FLPEQPGPAPQTVEKNSRPQ EGTGRRGSSEARPYCCNYEN CGKAYTKRSHLVSHQRKHTG ERPYSCNWESCSWSFFRSDE LRRHMRVHTRYRPYKCDQCS REFMRSDHLKQHQKTHRPGP SDPQANNNNGEQDSPPAAGP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-389 of human KLF17 (NP_775755.3). |
| Function | Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. |
| Protein Name | Krueppel-Like Factor 17Zinc Finger Protein 393 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 17 antibodyAnti-Zinc Finger Protein 393 antibodyAnti-KLF17 antibodyAnti-ZNF393 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and B4GALT1 knockout (KO) HeLa cells, using [KO Validated] B4GALT1 Rabbit pAb (STJ111285) at 1:3000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/91703/408543/STJ111285_1__83305.1744894851.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and B4GALT1 knockout (KO) HeLa cells, using [KO Validated] B4GALT1 Rabbit pAb (STJ111285) at 1:3000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.")
