| Short Description : | Goat polyclonal antibody anti-KLF15 (N-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications: | Pep-ELISA/WB/FC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 45kDa band observed in HeLa and in nuclear cell lysates of HepG2 (calculated MW of 44kDa according to NP_054798.1). Recommended concentration: 0.3-1µg/ml. Primary incubation 1 h |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | KLF15 |
| Gene ID: | 28999 |
| Uniprot ID: | KLF15_HUMAN |
| Accession Number: | NP_054798.1 |
| Immunogen Region: | N-Term |
| Immunogen Sequence: | VDHLLPVDENFSS |
| Function | Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4. Involved in podocyte differentiation. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. |
| Protein Name | Krueppel-Like Factor 15Kidney-Enriched Krueppel-Like Factor |
| Database Links | Reactome: R-HSA-1368108 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 15 antibodyAnti-Kidney-Enriched Krueppel-Like Factor antibodyAnti-KLF15 antibodyAnti-KKLF antibody |
Information sourced from Uniprot.org
