| Tissue Specificity | Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. |
| Function | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. |
| Protein Name | Chromosome-Associated Kinesin Kif4aChromokinesin-A |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-437239Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonSpindleMidbodyChromosomeAssociates With Chromosomes At All Stage Of MitosisChromatin Localization Is Dependent On Iron-Sulfur Cluster BindingIn AnaphaseAssociates With The Mitotic Spindle MidzoneIn Telophase And CytokinesisCo-Localizes With Ciao2b At The Spindle Midzone And MidbodyCo-Localizes With Prc1 In Early Mitosis And At The Spindle Midzone From Anaphase B To TelophaseDoes Not Localize To The Nucleolus |
| Alternative Antibody Names | Anti-Chromosome-Associated Kinesin Kif4a antibodyAnti-Chromokinesin-A antibodyAnti-KIF4A antibodyAnti-KIF4 antibody |
Information sourced from Uniprot.org
