Anti-KIF4A antibody [R03-8E4] (STJA0037267)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human KIF4A
General Information
| Short Description | Rabbit monoclonal anti-KIF4A for use in WB and FC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-8E4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | KIF4A |
| Gene ID | 24137 |
| Uniprot ID | KIF4A_HUMAN |
| Immunogen | A synthesized peptide derived from human KIF4A |
Additional Info
| Tissue Specificity | Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. |
| Function | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. |
| Protein Name | Chromosome-Associated Kinesin Kif4aChromokinesin-A |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-437239Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonSpindleMidbodyChromosomeAssociates With Chromosomes At All Stage Of MitosisChromatin Localization Is Dependent On Iron-Sulfur Cluster BindingIn AnaphaseAssociates With The Mitotic Spindle MidzoneIn Telophase And CytokinesisCo-Localizes With Ciao2b At The Spindle Midzone And MidbodyCo-Localizes With Prc1 In Early Mitosis And At The Spindle Midzone From Anaphase B To TelophaseDoes Not Localize To The Nucleolus |
| Alternative Antibody Names | Anti-Chromosome-Associated Kinesin Kif4a antibodyAnti-Chromokinesin-A antibodyAnti-KIF4A antibodyAnti-KIF4 antibody |
Information sourced from Uniprot.org