Anti-KIF4A antibody (1171-1220 aa) (STJ93837)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KIF4A at the amino acid range 1171-1220
General Information
| Short Description | Rabbit polyclonal anti-Chromosome-associated kinesin KIF4A (1171-1220 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF4A |
| Gene ID | 24137 |
| Uniprot ID | KIF4A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KIF4A at the amino acid range 1171-1220 |
| Immunogen Region | 1171-1220 aa |
| Specificity | KIF4A Polyclonal Antibody detects endogenous levels of KIF4A protein. |
Additional Info
| Function | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. |
| Protein Name | Chromosome-Associated Kinesin Kif4aChromokinesin-A |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-437239Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonSpindleMidbodyChromosomeAssociates With Chromosomes At All Stage Of MitosisChromatin Localization Is Dependent On Iron-Sulfur Cluster BindingIn AnaphaseAssociates With The Mitotic Spindle MidzoneIn Telophase And CytokinesisCo-Localizes With Ciao2b At The Spindle Midzone And MidbodyCo-Localizes With Prc1 In Early Mitosis And At The Spindle Midzone From Anaphase B To TelophaseDoes Not Localize To The Nucleolus |
| Alternative Antibody Names | Anti-Chromosome-Associated Kinesin Kif4a antibodyAnti-Chromokinesin-A antibodyAnti-KIF4A antibodyAnti-KIF4 antibody |
Information sourced from Uniprot.org