| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF13A |
| Gene ID: | 63971 |
| Uniprot ID: | KI13A_HUMAN |
| Immunogen Region: | 1300-1600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1300-1600 of human KIF13A (NP_001099036.1). |
| Immunogen Sequence: | SCGVTYEIVSNIPKATEEIE DRETLALLAARSENEGTSDG ETYIEKYTRGVLQVENILSL ERLRQAVTVKEALSTKARHI RRSLSTPNVHNVSSSRPDLS GFDEDDKGWPENQLDMSDYS SSYQDVACYGTLPRDSPRRN KEGCTSETPHALTVSPFKAF SPQPPKFFKPLMPVKEEHKK RIALEARPLLSQEDSEEEEN ELEAINRKLISSQPYVPVEF ADFSVYNASLENREWFSSK |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain and skeletal muscle. |
| Function | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. |
| Protein Name | Kinesin-Like Protein Kif13a Kinesin-Like Protein Rbkin |
| Database Links | Reactome: R-HSA-390471 |
| Cellular Localisation | Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Midbody Endosome Membrane Golgi Apparatus Membrane Recruited To The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif13a antibody Anti-Kinesin-Like Protein Rbkin antibody Anti-KIF13A antibody Anti-RBKIN antibody |
Information sourced from Uniprot.org