Anti-KIF13A antibody (1300-1600) (STJ118325)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIF13A (1300-1600) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF13A |
| Gene ID | 63971 |
| Uniprot ID | KI13A_HUMAN |
| Immunogen Region | 1300-1600 |
| Immunogen Sequence | SCGVTYEIVSNIPKATEEIE DRETLALLAARSENEGTSDG ETYIEKYTRGVLQVENILSL ERLRQAVTVKEALSTKARHI RRSLSTPNVHNVSSSRPDLS GFDEDDKGWPENQLDMSDYS SSYQDVACYGTLPRDSPRRN KEGCTSETPHALTVSPFKAF SPQPPKFFKPLMPVKEEHKK RIALEARPLLSQEDSEEEEN ELEAINRKLISSQPYVPVEF ADFSVYNASLENREWFSSK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1300-1600 of human KIF13A (NP_001099036.1). |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in heart, brain and skeletal muscle. |
| Function | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. |
| Protein Name | Kinesin-Like Protein Kif13aKinesin-Like Protein Rbkin |
| Database Links | Reactome: R-HSA-390471 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMidbodyEndosome MembraneGolgi Apparatus MembraneRecruited To The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif13a antibodyAnti-Kinesin-Like Protein Rbkin antibodyAnti-KIF13A antibodyAnti-RBKIN antibody |
Information sourced from Uniprot.org