Anti-Kdm6b antibody (90-190) (STJ114640)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Kdm6b (90-190) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Kdm6b |
| Gene ID | 216850 |
| Uniprot ID | KDM6B_MOUSE |
| Immunogen Region | 90-190 |
| Immunogen Sequence | LESLHGCVQALLREPAQPGL WEQLGQLYESEHDSEEAVCC YHRALRYGGSFAELGPRIGR LQQAQLWNFHAGSCQHRAKV LPPLEQVWNLLHLEHKRNYG A |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of mouse Kdm6b (NP_001017426.1). |
Additional Info
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex. |
| Protein Name | Lysine-Specific Demethylase 6bJmjc Domain-Containing Protein 3Jumonji Domain-Containing Protein 3Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b |
| Database Links | Reactome: R-MMU-2559580Reactome: -MMU-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6b antibodyAnti-Jmjc Domain-Containing Protein 3 antibodyAnti-Jumonji Domain-Containing Protein 3 antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b antibodyAnti-Kdm6b antibodyAnti-Jmjd3 antibodyAnti-Kiaa0346 antibody |
Information sourced from Uniprot.org