Immunocytochemistry of HeLa cells using anti-KDM5C/Jarid1C/SMCX mouse mAb diluted 1:150.

Anti-KDM5C antibody [2E4-E1-G8] (STJ99023)

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STJ99023
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Short Description :Mouse monoclonal anti-Lysine-specific demethylase 5C demethylase 5C for use in WB and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ICC
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :2E4-E1-G8
Isotype:IgG2a
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Dilution Range:WB 1:1000
ICC 1:150
Formulation:Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:KDM5C
Gene ID:8242
Uniprot ID:KDM5C_HUMAN
Immunogen:Purified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli
Specificity:This antibody detects endogenous levels of KDM5C/Jarid1C/SMCX and does not corss-react with related proteins
Function Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Name Lysine-Specific Demethylase 5c
Histone Demethylase Jarid1c
Jumonji/Arid Domain-Containing Protein 1c
Protein Smcx
Protein Xe169
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Lysine-Specific Demethylase 5c antibody
Anti-Histone Demethylase Jarid1c antibody
Anti-Jumonji/Arid Domain-Containing Protein 1c antibody
Anti-Protein Smcx antibody
Anti-Protein Xe169 antibody
Anti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibody
Anti-KDM5C antibody
Anti-DXS1272E antibody
Anti-JARID1C antibody
Anti-SMCX antibody
Anti-XE169 antibody

Information sourced from Uniprot.org

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