| Host: |
Mouse |
| Applications: |
WB/ICC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Lysine-specific demethylase 5C demethylase 5C is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
2E4-E1-G8 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000ICC 1:150 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM5C |
| Gene ID: |
8242 |
| Uniprot ID: |
KDM5C_HUMAN |
| Specificity: |
This antibody detects endogenous levels of KDM5C/Jarid1C/SMCX and does not corss-react with related proteins |
| Immunogen: |
Purified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5cHistone Demethylase Jarid1cJumonji/Arid Domain-Containing Protein 1cProtein SmcxProtein Xe169Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5c antibodyAnti-Histone Demethylase Jarid1c antibodyAnti-Jumonji/Arid Domain-Containing Protein 1c antibodyAnti-Protein Smcx antibodyAnti-Protein Xe169 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibodyAnti-KDM5C antibodyAnti-DXS1272E antibodyAnti-JARID1C antibodyAnti-SMCX antibodyAnti-XE169 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
