| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5bCancer/Testis Antigen 31Ct31Histone Demethylase Jarid1bJumonji/Arid Domain-Containing Protein 1bPlu-1Retinoblastoma-Binding Protein 2 Homolog 1Rbp2-H1Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-8866911Reactome: R-HSA-9821002 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5b antibodyAnti-Cancer/Testis Antigen 31 antibodyAnti-Ct31 antibodyAnti-Histone Demethylase Jarid1b antibodyAnti-Jumonji/Arid Domain-Containing Protein 1b antibodyAnti-Plu-1 antibodyAnti-Retinoblastoma-Binding Protein 2 Homolog 1 antibodyAnti-Rbp2-H1 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b antibodyAnti-KDM5B antibodyAnti-JARID1B antibodyAnti-PLU1 antibodyAnti-RBBP2H1 antibody |
Information sourced from Uniprot.org
