| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KDM5B |
| Gene ID: | 10765 |
| Uniprot ID: | KDM5B_HUMAN |
| Immunogen Region: | 784-883 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-883 of human KDM5B (NP_006609.3). |
| Immunogen Sequence: | EESEMKKFPDNDLLRHLRLV TQDAEKCASVAQQLLNGKRQ TRYRSGGGKSQNQLTVNELR QFVTQLYALPCVLSQTPLLK DLLNRVEDFQQHSQKLLSEE |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5b Cancer/Testis Antigen 31 Ct31 Histone Demethylase Jarid1b Jumonji/Arid Domain-Containing Protein 1b Plu-1 Retinoblastoma-Binding Protein 2 Homolog 1 Rbp2-H1 Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b |
| Database Links | Reactome: R-HSA-3214842 Reactome: R-HSA-8866911 Reactome: R-HSA-9821002 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5b antibody Anti-Cancer/Testis Antigen 31 antibody Anti-Ct31 antibody Anti-Histone Demethylase Jarid1b antibody Anti-Jumonji/Arid Domain-Containing Protein 1b antibody Anti-Plu-1 antibody Anti-Retinoblastoma-Binding Protein 2 Homolog 1 antibody Anti-Rbp2-H1 antibody Anti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b antibody Anti-KDM5B antibody Anti-JARID1B antibody Anti-PLU1 antibody Anti-RBBP2H1 antibody |
Information sourced from Uniprot.org