| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-KDM5A (1400-1690) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S7MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IP 1:100-1:500ChIP 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM5A |
| Gene ID: |
5927 |
| Uniprot ID: |
KDM5A_HUMAN |
| Immunogen Region: |
1400-1690 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375). |
| Immunogen Sequence: |
HAYSSASKSCSQGSSTPRKQ PRKSPLVPRSLEPPVLELSP GAKAQLEELMMVGDLLEVSL DETQHIWRILQATHPPSEDR FLHIMEDDSMEEKPLKVKGK DSSEKKRKRKLEKVEQLFGE GKQKSKELKKMDKPRKKKLK LGADKSKELNKLAKKLAKEE ERKKKKEKAAAAKVELVKES TEKKREKKVLDIPSKYDWSG AEESDDENAVCAAQNCQRPC KDKVDWVQCDGGCDEWFHQ |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells. |
| Protein Name | Lysine-Specific Demethylase 5aHistone Demethylase Jarid1aJumonji/Arid Domain-Containing Protein 1aRetinoblastoma-Binding Protein 2Rbbp-2Histone H3-Trimethyl-L-Lysine(4 Demethylase 5a |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | NucleusNucleolusOccupies Promoters Of Genes Involved In Rna Metabolism And Mitochondrial Function |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5a antibodyAnti-Histone Demethylase Jarid1a antibodyAnti-Jumonji/Arid Domain-Containing Protein 1a antibodyAnti-Retinoblastoma-Binding Protein 2 antibodyAnti-Rbbp-2 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5a antibodyAnti-KDM5A antibodyAnti-JARID1A antibodyAnti-RBBP2 antibodyAnti-RBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
