Anti-KDM4B antibody (1-1096) (STJ28387)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KDM4B (1-1096) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM4B |
| Gene ID | 23030 |
| Uniprot ID | KDM4B_HUMAN |
| Immunogen Region | 1-1096 |
| Immunogen Sequence | MGSEDHGAQNPSCKIMTFRP TMEEFKDFNKYVAYIESQGA HRAGLAKIIPPKEWKPRQTY DDIDDVVIPAPIQQVVTGQS GLFTQYNIQKKAMTVGEYRR LANSEKYCTPRHQDFDDLER KYWKNLTFVSPIYGADISGS LYDDDVAQWNIGSLRTILDM VERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINY LHFGEPKSWYAIPPEHGKRL ERLAIGFFPGSSQGCDAFL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1). |
Additional Info
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS). |
| Protein Name | Lysine-Specific Demethylase 4bJmjc Domain-Containing Histone Demethylation Protein 3bJumonji Domain-Containing Protein 2bHistone H3-Trimethyl-L-Lysine(9 Demethylase 4b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5693565Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4b antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3b antibodyAnti-Jumonji Domain-Containing Protein 2b antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4b antibodyAnti-KDM4B antibodyAnti-JHDM3B antibodyAnti-JMJD2B antibodyAnti-KIAA0876 antibody |
Information sourced from Uniprot.org