• Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-KCTD6 antibody (118-168 aa) (STJ194800)

SKU:
STJ194800

Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BTB/POZ domain-containing protein KCTD6 (118-168 aa) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCTD6
Gene ID: 200845
Uniprot ID: KCTD6_HUMAN
Immunogen Region: 118-168 aa
Specificity: This antibody detects endogenous levels of KCTD6 at Human/Mouse
Immunogen: Synthesized peptide derived from the human KCTD6 at the amino acid range 118-168
Function Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1.the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Protein Name Btb/Poz Domain-Containing Protein Kctd6
Kcash3 Protein
Potassium Channel Tetramerization Domain-Containing Protein 6
Database Links Reactome: R-HSA-8931987
Reactome: R-HSA-8951664
Reactome: R-HSA-9018519
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Myofibril
Sarcomere
M Line
Colocalizes With Ank1 Isoform Mu17 At The M Line In Differentiated Skeletal Muscle Cells And Heart
Alternative Antibody Names Anti-Btb/Poz Domain-Containing Protein Kctd6 antibody
Anti-Kcash3 Protein antibody
Anti-Potassium Channel Tetramerization Domain-Containing Protein 6 antibody
Anti-KCTD6 antibody

Information sourced from Uniprot.org

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