| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BTB/POZ domain-containing protein KCTD6 (118-168 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCTD6 |
| Gene ID: |
200845 |
| Uniprot ID: |
KCTD6_HUMAN |
| Immunogen Region: |
118-168 aa |
| Specificity: |
This antibody detects endogenous levels of KCTD6 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human KCTD6 at the amino acid range 118-168 |
| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1.the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation. |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd6Kcash3 ProteinPotassium Channel Tetramerization Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8931987Reactome: R-HSA-8951664Reactome: R-HSA-9018519Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereM LineColocalizes With Ank1 Isoform Mu17 At The M Line In Differentiated Skeletal Muscle Cells And Heart |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd6 antibodyAnti-Kcash3 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 6 antibodyAnti-KCTD6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
