Anti-KCTD6 antibody (118-168 aa) (STJ194800)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human KCTD6 at the amino acid range 118-168
General Information
| Short Description | Rabbit polyclonal anti-BTB/POZ domain-containing protein KCTD6 (118-168 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCTD6 |
| Gene ID | 200845 |
| Uniprot ID | KCTD6_HUMAN |
| Immunogen | Synthesized peptide derived from the human KCTD6 at the amino acid range 118-168 |
| Immunogen Region | 118-168 aa |
| Specificity | This antibody detects endogenous levels of KCTD6 at Human/Mouse |
Additional Info
| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1.the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation. |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd6Kcash3 ProteinPotassium Channel Tetramerization Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8931987Reactome: R-HSA-8951664Reactome: R-HSA-9018519Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereM LineColocalizes With Ank1 Isoform Mu17 At The M Line In Differentiated Skeletal Muscle Cells And Heart |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd6 antibodyAnti-Kcash3 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 6 antibodyAnti-KCTD6 antibody |
Information sourced from Uniprot.org