Anti-KCNK6 antibody (C-Term) (STJ13101282)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal region of human KCNK6 (TOSS, TWIK2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNK6 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNK6 |
| Gene ID | 9424 |
| Uniprot ID | KCNK6_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal region of human KCNK6 (TOSS, TWIK2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for KCNK6. |
Additional Info
| Post Translational Modifications | N-glycosylation is necessary for targeting to lysosomes. |
| Function | K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux. Isoform 2: Does not display channel activity. |
| Protein Name | Potassium Channel Subfamily K Member 6Inward Rectifying Potassium Channel Protein Twik-2Twik-Originated Similarity Sequence |
| Database Links | Reactome: R-HSA-1299308Reactome: R-HSA-5576886 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 6 antibodyAnti-Inward Rectifying Potassium Channel Protein Twik-2 antibodyAnti-Twik-Originated Similarity Sequence antibodyAnti-KCNK6 antibodyAnti-TOSS antibodyAnti-TWIK2 antibody |
Information sourced from Uniprot.org