| Post Translational Modifications | N-glycosylation is necessary for targeting to lysosomes. |
| Function | K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux. Isoform 2: Does not display channel activity. |
| Protein Name | Potassium Channel Subfamily K Member 6Inward Rectifying Potassium Channel Protein Twik-2Twik-Originated Similarity Sequence |
| Database Links | Reactome: R-HSA-1299308Reactome: R-HSA-5576886 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 6 antibodyAnti-Inward Rectifying Potassium Channel Protein Twik-2 antibodyAnti-Twik-Originated Similarity Sequence antibodyAnti-KCNK6 antibodyAnti-TOSS antibodyAnti-TWIK2 antibody |
Information sourced from Uniprot.org
