| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCND3 (521-655) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCND3 |
| Gene ID: |
3752 |
| Uniprot ID: |
KCND3_HUMAN |
| Immunogen Region: |
521-655 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 521-655 of human KCND3 (NP_004971.2). |
| Immunogen Sequence: |
MESSMQNYPSTRSPSLSSHP GLTTTCCSRRSKKTTHLPNS NLPATRLRSMQELSTIHIQG SEQPSLTTSRSSLNLKADDG LRPNCKTSQITTAIISIPTP PALTPEGESRPPPASPGPNT NIPSIASNVVKVSAL |
| Tissue Specificity | Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. |
| Post Translational Modifications | Regulated through phosphorylation at Ser-569 by CaMK2D. |
| Function | Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily D Member 3Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaCell ProjectionDendriteInteraction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibodyAnti-KCND3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
