Anti-KCND3 antibody (521-655) (STJ29007)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCND3 (521-655) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCND3 |
| Gene ID | 3752 |
| Uniprot ID | KCND3_HUMAN |
| Immunogen Region | 521-655 |
| Immunogen Sequence | MESSMQNYPSTRSPSLSSHP GLTTTCCSRRSKKTTHLPNS NLPATRLRSMQELSTIHIQG SEQPSLTTSRSSLNLKADDG LRPNCKTSQITTAIISIPTP PALTPEGESRPPPASPGPNT NIPSIASNVVKVSAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 521-655 of human KCND3 (NP_004971.2). |
Additional Info
| Tissue Specificity | Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Regulated through phosphorylation at Ser-569 by CaMK2D. |
| Function | Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd3Potassium Voltage-Gated Channel Subfamily D Member 3Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaCell ProjectionDendriteInteraction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd3 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibodyAnti-KCND3 antibody |
Information sourced from Uniprot.org