Anti-JUP antibody (C-Term) (STJA0005308)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenGamma-Catenin synthetic peptide (coupled to KLH) corresponding to amino acid residues from the C-terminal region of human Gamma-Catenin. This peptide sequence is highly conserved in rat and mouse Gamma-Catenin.
General Information
| Short Description | Rabbit polyclonal antibody anti-Gamma-Catenin (C-Term) is suitable for use in Western Blot research applications. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JUP |
| Gene ID | 3728 |
| Uniprot ID | PLAK_HUMAN |
| Immunogen | Gamma-Catenin synthetic peptide (coupled to KLH) corresponding to amino acid residues from the C-terminal region of human Gamma-Catenin. This peptide sequence is highly conserved in rat and mouse Gamma-Catenin. |
| Immunogen Region | C-Term |
| Specificity | The antibody detects an 84kDa* protein corresponding to the molecular mass of Gamma-Catenin on SDS-PAGE immunoblots of A431 cells. |
Additional Info
| Tissue Specificity | Expressed in the heart (at protein level). |
| Post Translational Modifications | May be phosphorylated by FER. |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Protein Name | Junction PlakoglobinCatenin GammaDesmoplakin IiiDesmoplakin-3 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeCytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinNucleusCytoplasmic In A Soluble And Membrane-Associated FormColocalizes With Dsg4 At Desmosomes |
| Alternative Antibody Names | Anti-Junction Plakoglobin antibodyAnti-Catenin Gamma antibodyAnti-Desmoplakin Iii antibodyAnti-Desmoplakin-3 antibodyAnti-JUP antibodyAnti-CTNNG antibodyAnti-DP3 antibody |
Information sourced from Uniprot.org