Anti-JUP antibody (C-Term) (STJA0005308)

SKU:
STJA0005308-100

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Gamma-Catenin (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: JUP
Gene ID: 3728
Uniprot ID: PLAK_HUMAN
Immunogen Region: C-Term
Specificity: The antibody detects an 84kDa* protein corresponding to the molecular mass of Gamma-Catenin on SDS-PAGE immunoblots of A431 cells.
Immunogen: Gamma-Catenin synthetic peptide (coupled to KLH) corresponding to amino acid residues from the C-terminal region of human Gamma-Catenin. This peptide sequence is highly conserved in rat and mouse Gamma-Catenin.
Tissue Specificity Expressed in the heart (at protein level).
Post Translational Modifications May be phosphorylated by FER.
Function Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Protein Name Junction Plakoglobin
Catenin Gamma
Desmoplakin Iii
Desmoplakin-3
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013409
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Cell Junction
Adherens Junction
Desmosome
Cytoplasm
Cytoskeleton
Membrane
Peripheral Membrane Protein
Cytoplasmic In A Soluble And Membrane-Associated Form
Alternative Antibody Names Anti-Junction Plakoglobin antibody
Anti-Catenin Gamma antibody
Anti-Desmoplakin Iii antibody
Anti-Desmoplakin-3 antibody
Anti-JUP antibody
Anti-CTNNG antibody
Anti-DP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance