| Host: |
Rabbit |
| Applications: |
IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITPR2 |
| Gene ID: |
3709 |
| Uniprot ID: |
ITPR2_HUMAN |
| Immunogen Region: |
2415-2480 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2415-2480 of human ITPR2 (NP_002214.2). |
| Immunogen Sequence: |
LFLKDDFTMEVDRLKNRTPV TGSHQVPTMTLTTMMEACAK ENCSPTIPASNTADEEYEDG IERTCD |
| Tissue Specificity | Isoform Short: Found in skeletal muscle and heart. |
| Post Translational Modifications | Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2Ip3 Receptor Isoform 2Ip3r 2Insp3r2Inositol 1 -4 -5-Trisphosphate Receptor Type 2Type 2 Inositol 1 -4 -5-Trisphosphate ReceptorType 2 Insp3 Receptor |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-1489509Reactome: R-HSA-2029485Reactome: R-HSA-2871809Reactome: R-HSA-381676Reactome: R-HSA-4086398Reactome: R-HSA-422356Reactome: R-HSA-5218921Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-9664323Reactome: R-HSA-983695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory Vesicle MembraneForms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 145-Trisphosphate Binding |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibodyAnti-Ip3 Receptor Isoform 2 antibodyAnti-Ip3r 2 antibodyAnti-Insp3r2 antibodyAnti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibodyAnti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibodyAnti-Type 2 Insp3 Receptor antibodyAnti-ITPR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
