| Short Description : | Rabbit monoclonal IRF6 (368-467) antibody for use in WB, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IRF6 |
| Gene ID: | 3664 |
| Uniprot ID: | IRF6_HUMAN |
| Immunogen Region: | 368-467 |
| Immunogen Sequence: | PFEIYLCFGEEWPDGKPLER KLILVQVIPVVARMIYEMFS GDFTRSFDSGSVRLQISTPD IKDNIVAQLKQLYRILQTQE SWQPMQPTPSMQLPPALPPQ |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896). |
| Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. |
| Post Translational Modifications | Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. |
| Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. |
| Protein Name | Interferon Regulatory Factor 6Irf-6 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusCytoplasmTranslocates To Nucleus In Response To An Activating Signal |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 6 antibodyAnti-Irf-6 antibodyAnti-IRF6 antibody |
Information sourced from Uniprot.org
