Anti-IRAG2 antibody (STJA0008516)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LRMP
General Information
| Short Description | Rabbit polyclonal anti-Inositol 1, 4, 5-triphosphate receptor associated 2 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IRAG2 |
| Gene ID | 4033 |
| Uniprot ID | IRAG2_HUMAN |
| Immunogen | Synthesized peptide derived from human LRMP |
| Specificity | This antibody detects endogenous levels of LRMP at Human |
Additional Info
| Post Translational Modifications | The removal of the C-terminal lumenal domain occurs by proteolytic processing. |
| Function | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules.this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity. |
| Protein Name | Inositol 1 -4 -5-Triphosphate Receptor Associated 2Lymphoid-Restricted Membrane ProteinProtein Jaw1 Cleaved Into - Processed Inositol 1 -4 -5-Triphosphate Receptor Associated 2 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Processed Inositol 145-Triphosphate Receptor Associated 2: CytoplasmEndoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinNucleus EnvelopeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleChromosomeColocalized With Itpr3 On The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Triphosphate Receptor Associated 2 antibodyAnti-Lymphoid-Restricted Membrane Protein antibodyAnti-Protein Jaw1 Cleaved Into - Processed Inositol 1 -4 -5-Triphosphate Receptor Associated 2 antibodyAnti-IRAG2 antibodyAnti-JAW1 antibodyAnti-LRMP antibody |
Information sourced from Uniprot.org