Anti-IPO13 antibody (484-534 aa) (STJ193723)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human IPO13 at the amino acid range 484-534
General Information
| Short Description | Rabbit polyclonal anti-Importin-13 (484-534 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IPO13 |
| Gene ID | 9670 |
| Uniprot ID | IPO13_HUMAN |
| Immunogen | Synthesized peptide derived from the human IPO13 at the amino acid range 484-534 |
| Immunogen Region | 484-534 aa |
| Specificity | This antibody detects endogenous levels of IPO13 at Human/Mouse/Rat |
Additional Info
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. |
| Protein Name | Importin-13Imp13Karyopherin-13Kap13Ran-Binding Protein 13Ranbp13 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-13 antibodyAnti-Imp13 antibodyAnti-Karyopherin-13 antibodyAnti-Kap13 antibodyAnti-Ran-Binding Protein 13 antibodyAnti-Ranbp13 antibodyAnti-IPO13 antibodyAnti-KIAA0724 antibodyAnti-RANBP13 antibody |
Information sourced from Uniprot.org