| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. |
| Protein Name | Importin-13Imp13Karyopherin-13Kap13Ran-Binding Protein 13Ranbp13 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-13 antibodyAnti-Imp13 antibodyAnti-Karyopherin-13 antibodyAnti-Kap13 antibodyAnti-Ran-Binding Protein 13 antibodyAnti-Ranbp13 antibodyAnti-IPO13 antibodyAnti-KIAA0724 antibodyAnti-RANBP13 antibody |
Information sourced from Uniprot.org
