Anti-INPP5E antibody (510-630) (STJ119776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INPP5E (510-630) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP5E |
| Gene ID | 56623 |
| Uniprot ID | INP5E_HUMAN |
| Immunogen Region | 510-630 |
| Immunogen Sequence | LIREMRKGSIFKGFQEPDIH FLPSYKFDIGKDTYDSTSKQ RTPSYTDRVLYRSRHKGDIC PVSYSSCPGIKTSDHRPVYG LFRVKVRPGRDNIPLAAGKF DRELYLLGIKRRISKEIQRQ Q |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
Additional Info
| Tissue Specificity | Detected in brain, heart, pancreas, testis and spleen. |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability. |
| Protein Name | Phosphatidylinositol Polyphosphate 5-Phosphatase Type Iv72 Kda Inositol Polyphosphate 5-PhosphataseInositol Polyphosphate-5-Phosphatase EPhosphatidylinositol 4 -5-Bisphosphate 5-PhosphatasePhosphatidylinositol-3 -4 -5-Trisphosphate 5-Phosphatase |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-5624958 |
| Cellular Localisation | CytoplasmCytoskeletonCilium AxonemeGolgi ApparatusGolgi Stack MembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionRuffleNucleusPeripheral Membrane Protein Associated With Golgi Stacks |
| Alternative Antibody Names | Anti-Phosphatidylinositol Polyphosphate 5-Phosphatase Type Iv antibodyAnti-72 Kda Inositol Polyphosphate 5-Phosphatase antibodyAnti-Inositol Polyphosphate-5-Phosphatase E antibodyAnti-Phosphatidylinositol 4 -5-Bisphosphate 5-Phosphatase antibodyAnti-Phosphatidylinositol-3 -4 -5-Trisphosphate 5-Phosphatase antibodyAnti-INPP5E antibody |
Information sourced from Uniprot.org