Anti-INO80 antibody (STJA0004874)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human INO80
General Information
| Short Description | Rabbit polyclonal anti-Chromatin-Remodeling Atpase Ino80 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 2.46 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | INO80 |
| Gene ID | 54617 |
| Uniprot ID | INO80_HUMAN |
| Immunogen | Synthetic peptide of human INO80 |
Additional Info
| Tissue Specificity | widely expressed. specifically expressed in brain, liver and pancreas. |
| Function | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle. |
| Protein Name | Chromatin-Remodeling Atpase Ino80Hino80Dna Helicase-Related Ino80 Complex Homolog 1Dna Helicase-Related Protein Ino80Ino80 Complex Subunit A |
| Database Links | Reactome: R-HSA-5689603Reactome: R-HSA-5696394 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonSpindleChromosomeLocalizes To The Cytoplasm In Quiescent CellAssociates With Spindle Microtubules During MitosisColocalizes With Pcna At Replication Forks During S-PhaseRecruited To Dna Damage Sites In A Actr8-Dependent Manner |
| Alternative Antibody Names | Anti-Chromatin-Remodeling Atpase Ino80 antibodyAnti-Hino80 antibodyAnti-Dna Helicase-Related Ino80 Complex Homolog 1 antibodyAnti-Dna Helicase-Related Protein Ino80 antibodyAnti-Ino80 Complex Subunit A antibodyAnti-INO80 antibodyAnti-INO80A antibodyAnti-INOC1 antibodyAnti-KIAA1259 antibody |
Information sourced from Uniprot.org