Host: | Rabbit |
Applications: | IHC/ELISA |
Reactivity: | Human/Mouse |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Chromatin-Remodeling Atpase Ino80 is suitable for use in Immunohistochemistry and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification: | Antigen affinity purification |
Concentration: | 2.46 mg/mL |
Dilution Range: | IHC 1:50-1:300 |
Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
Gene Symbol: | INO80 |
Gene ID: | 54617 |
Uniprot ID: | INO80_HUMAN |
Immunogen: | Synthetic peptide of human INO80 |
Tissue Specificity | widely expressed. specifically expressed in brain, liver and pancreas. |
Function | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle. |
Protein Name | Chromatin-Remodeling Atpase Ino80 Hino80 Dna Helicase-Related Ino80 Complex Homolog 1 Dna Helicase-Related Protein Ino80 Ino80 Complex Subunit A |
Database Links | Reactome: R-HSA-5689603 Reactome: R-HSA-5696394 |
Cellular Localisation | Cytoplasm Nucleus Cytoskeleton Spindle Chromosome Localizes To The Cytoplasm In Quiescent Cell Associates With Spindle Microtubules During Mitosis Colocalizes With Pcna At Replication Forks During S-Phase Recruited To Dna Damage Sites In A Actr8-Dependent Manner |
Alternative Antibody Names | Anti-Chromatin-Remodeling Atpase Ino80 antibody Anti-Hino80 antibody Anti-Dna Helicase-Related Ino80 Complex Homolog 1 antibody Anti-Dna Helicase-Related Protein Ino80 antibody Anti-Ino80 Complex Subunit A antibody Anti-INO80 antibody Anti-INO80A antibody Anti-INOC1 antibody Anti-KIAA1259 antibody |
Information sourced from Uniprot.org