Anti-INO80 antibody (STJA0004874)

SKU:
STJA0004874

Current Stock:
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human/Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chromatin-Remodeling Atpase Ino80 is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification: Antigen affinity purification
Concentration: 2.46 mg/mL
Dilution Range: IHC 1:50-1:300
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: INO80
Gene ID: 54617
Uniprot ID: INO80_HUMAN
Immunogen: Synthetic peptide of human INO80
Tissue Specificity widely expressed. specifically expressed in brain, liver and pancreas.
Function ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Protein Name Chromatin-Remodeling Atpase Ino80
Hino80
Dna Helicase-Related Ino80 Complex Homolog 1
Dna Helicase-Related Protein Ino80
Ino80 Complex Subunit A
Database Links Reactome: R-HSA-5689603
Reactome: R-HSA-5696394
Cellular Localisation Cytoplasm
Nucleus
Cytoskeleton
Spindle
Chromosome
Localizes To The Cytoplasm In Quiescent Cell
Associates With Spindle Microtubules During Mitosis
Colocalizes With Pcna At Replication Forks During S-Phase
Recruited To Dna Damage Sites In A Actr8-Dependent Manner
Alternative Antibody Names Anti-Chromatin-Remodeling Atpase Ino80 antibody
Anti-Hino80 antibody
Anti-Dna Helicase-Related Ino80 Complex Homolog 1 antibody
Anti-Dna Helicase-Related Protein Ino80 antibody
Anti-Ino80 Complex Subunit A antibody
Anti-INO80 antibody
Anti-INO80A antibody
Anti-INOC1 antibody
Anti-KIAA1259 antibody

Information sourced from Uniprot.org