| Short Description : | Rabbit polyclonal IMPDH1 (434-563) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IMPDH1 |
| Gene ID: | 3614 |
| Uniprot ID: | IMDH1_HUMAN |
| Immunogen Region: | 434-563 |
| Immunogen Sequence: | MMGSLLAATTEAPGEYFFSD GVRLKKYRGMGSLDAMEKSS SSQKRYFSEGDKVKIAQGVS GSIQDKGSIQKFVPYLIAGI QHGCQDIGARSLSVLRSMMY SGELKFEKRTMSAQIEGGVH GLHSYEKRLY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 434-563 of human IMPDH1 (NP_899066.1). |
| Tissue Specificity | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 1Imp Dehydrogenase 1Impd 1Impdh 1Impdh-I |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-73817Reactome: R-HSA-9679191Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 1 antibodyAnti-Imp Dehydrogenase 1 antibodyAnti-Impd 1 antibodyAnti-Impdh 1 antibodyAnti-Impdh-I antibodyAnti-IMPDH1 antibodyAnti-IMPD1 antibody |
Information sourced from Uniprot.org
