• Western blot analysis of extracts of various cell lines, using IMPDH1 rabbit polyclonal antibody (STJ111723) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
  • Immunofluorescence analysis of L929 cells using IMPDH1 Rabbit polyclonal antibody (STJ111723) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of L929 cells using IMPDH1 rabbit polyclonal antibody (STJ111723) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Western blot analysis of extracts of various cell lines, using IMPDH1 Rabbit polyclonal antibody (STJ111723) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-IMPDH1 antibody (434-563) (STJ111723)

SKU:
STJ111723

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IMPDH1 (434-563) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IMPDH1
Gene ID: 3614
Uniprot ID: IMDH1_HUMAN
Immunogen Region: 434-563
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 434-563 of human IMPDH1 (NP_899066.1).
Immunogen Sequence: MMGSLLAATTEAPGEYFFSD GVRLKKYRGMGSLDAMEKSS SSQKRYFSEGDKVKIAQGVS GSIQDKGSIQKFVPYLIAGI QHGCQDIGARSLSVLRSMMY SGELKFEKRTMSAQIEGGVH GLHSYEKRLY
Tissue Specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Protein Name Inosine-5'-Monophosphate Dehydrogenase 1
Imp Dehydrogenase 1
Impd 1
Impdh 1
Impdh-I
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-73817
Reactome: R-HSA-9679191
Reactome: R-HSA-9748787
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Inosine-5'-Monophosphate Dehydrogenase 1 antibody
Anti-Imp Dehydrogenase 1 antibody
Anti-Impd 1 antibody
Anti-Impdh 1 antibody
Anti-Impdh-I antibody
Anti-IMPDH1 antibody
Anti-IMPD1 antibody

Information sourced from Uniprot.org

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