| Function | Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate. |
| Protein Name | Inositol Monophosphatase 1Imp 1Impase 1D-Galactose 1-Phosphate PhosphataseInositol-1(Or 4-Monophosphatase 1Lithium-Sensitive Myo-Inositol Monophosphatase A1 |
| Database Links | Reactome: R-HSA-1855183 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Inositol Monophosphatase 1 antibodyAnti-Imp 1 antibodyAnti-Impase 1 antibodyAnti-D-Galactose 1-Phosphate Phosphatase antibodyAnti-Inositol-1(Or 4-Monophosphatase 1 antibodyAnti-Lithium-Sensitive Myo-Inositol Monophosphatase A1 antibodyAnti-IMPA1 antibodyAnti-IMPA antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and CBR1 knockout (KO) A-549 cells, using [KO Validated] CBR1 Rabbit polyclonal antibody (STJ11100047) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89119/357571/STJ11100047_1__35791.1713121699.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CBR1 knockout (KO) A-549 cells, using [KO Validated] CBR1 Rabbit polyclonal antibody (STJ11100047) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
