Anti-IMPA1 antibody (1-277) (STJ28464)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IMPA1 (1-277) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IMPA1 |
| Gene ID | 3612 |
| Uniprot ID | IMPA1_HUMAN |
| Immunogen Region | 1-277 |
| Immunogen Sequence | MADPWQECMDYAVTLARQAG EVVCEAIKNEMNVMLKSSPV DLVTATDQKVEKMLISSIKE KYPSHSFIGEESVAAGEKSI LTDNPTWIIDPIDGTTNFVH RFPFVAVSIGFAVNKKIEFG VVYSCVEGKMYTARKGKGAF CNGQKLQVSQQEDITKSLLV TELGSSRTPETVRMVLSNME KLFCIPVHGIRSVGTAAVNM CLVATGGADAYYEMGIHCWD VAGAGIIVTEAGGVLMDVT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1). |
Additional Info
| Function | Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate. |
| Protein Name | Inositol Monophosphatase 1Imp 1Impase 1D-Galactose 1-Phosphate PhosphataseInositol-1(Or 4-Monophosphatase 1Lithium-Sensitive Myo-Inositol Monophosphatase A1 |
| Database Links | Reactome: R-HSA-1855183 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Inositol Monophosphatase 1 antibodyAnti-Imp 1 antibodyAnti-Impase 1 antibodyAnti-D-Galactose 1-Phosphate Phosphatase antibodyAnti-Inositol-1(Or 4-Monophosphatase 1 antibodyAnti-Lithium-Sensitive Myo-Inositol Monophosphatase A1 antibodyAnti-IMPA1 antibodyAnti-IMPA antibody |
Information sourced from Uniprot.org