Anti-IL24 antibody (52-140) (STJ26183)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL24 (52-140) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL24 |
| Gene ID | 11009 |
| Uniprot ID | IL24_HUMAN |
| Immunogen Region | 52-140 |
| Immunogen Sequence | GQEFHFGPCQVKGVVPQKLW EAFWAVKDTMQAQDNITSAR LLQQEVLQNVSDAESCYLVH TLLEFYLKTVFKNYHNRTVE VRTLKSFST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 52-140 of human IL24 (NP_001172085.1). |
Additional Info
| Tissue Specificity | Up-regulated in melanoma cells induced to terminally differentiate. |
| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Melanoma Differentiation-Associated Gene 7 ProteinMda-7Suppression Of Tumorigenicity 16 Protein |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-24 antibodyAnti-Il-24 antibodyAnti-Melanoma Differentiation-Associated Gene 7 Protein antibodyAnti-Mda-7 antibodyAnti-Suppression Of Tumorigenicity 16 Protein antibodyAnti-IL24 antibodyAnti-MDA7 antibodyAnti-ST16 antibody |
Information sourced from Uniprot.org